Poloxamer CAS 9003-11-6

Pharmaceutical field

Drug preparation: Poloxam, as an emulsifier and stabilizer, is widely used in drug preparation, such as injections, oral solutions, soft capsules, etc. It can improve the drug's solubility and stability, improve its taste, and reduce side effects.

Drug delivery: Drug delivery carriers, such as microspheres and nanoparticles, can be prepared using poloxam's gel network structure and adhesion. These vectors can achieve sustained release and targeted delivery of drugs, improve drug efficacy and reduce side effects.

Drug dissolution improvement: Poloxam can improve the dissolution of the drug, thereby improving the bioavailability and absorption effect. This is particularly important for some insoluble drugs.

Food industry

Food additive: Poloxam as a food additive can improve the taste, texture and stability of food.

Food processing additives: In the food processing process, poloxam can be used as a defoamer, release agent, wetting agent and other additives to help achieve a smooth process.

Cosmetics

Preparation of lotions and creams: Poloxham, as an emulsifier and stabilizer, is widely used to prepare lotions and creams in cosmetics.

Moisturizing and moisturizing: Therefore, it is widely used in moisturizers, facial masks, lip balms and other cosmetics.

Moistening and adhesion of makeup products: Poloxham can be used as a wetting and adhesion agent in lipstick, eyeshadow, foundation, and other makeup products to improve the comfort and durability of products.

Personal care products

Bath products and detergents: In personal care products such as body washes, shampoos and hand sanitizers, Poloxam can be used as a foaming agent, wetting agent and cleaning agent to provide a good washing effect and a comfortable use experience.

Oral care products: In toothpaste, mouthwash and other oral care products, poloxam can be used as a foaming agent, wetting agent and stabilizer to improve the cleaning effect and use experience of the product.

Industrial field

Industrial cleaning: Poloxham can be used as an industrial cleaning agent, with good cleaning effects and environmental protection performance. 

Inks and coatings: In inks and coatings, Poloxam can be used as a leveling agent, thickener and stabilizer to improve product quality and stability.

Petroleum industry: Bloxham can be a stabilizer, thickener, and point depressant for water-in-oil emulsions to improve oil recovery and transportation efficiency.

Nanotechnology: Using Poloxham's gel network structure and interfacial activity, nanoparticles, nanofibers and other nanomaterials can be prepared and widely used in materials science, catalysis, sensors and other fields.

Production Method of  Poloxamer  :

Chemical synthesis

Chemical synthesis is the main method of producing poloxam, mainly block copolymerization, esterification, and hydrolysis. The following are the specific steps of chemical synthesis:

Block copolymerization: First, polyoxyethylene (PEO) and polypropylene (PPO) are block copolymerized to obtain the precursor of Poloxamer. This step is usually carried out by anionic polymerization or active polymerization. 

Esterification: The precursor is esterified with an appropriate amount of fatty alcohol to produce poloxam. The esterification reaction is usually carried out under the action of catalysts; commonly used catalysts include sulfuric acid, hydrochloric acid, and other acids. By controlling the conditions of the esterification reaction, such as temperature, pressure and reaction time, the molecular weight and purity of the product can be optimized.

Hydrolysis: Based on the esterification reaction, the product is hydrolyzed to improve the purity of poloxam further. Hydrolysis reactions are usually carried out under acidic or alkaline conditions to promote the hydrolysis of ester groups. After hydrolysis, Poloxham with high purity was obtained by refining and purification.

The advantages of chemical synthesis are high production efficiency, high product purity, and large-scale production. However, the chemical synthesis method needs to use various chemical raw materials and catalysts with a certain environmental pollution. Therefore, effective environmental protection measures should be taken in the production process to reduce waste generation and emissions.

Natural extraction method

In addition to chemical synthesis, another method of producing Bloxham is natural extraction. This method extracts the relevant components from natural plants and further processes them to obtain poloxam. Here are the steps of the natural extraction method:

Extraction: The extraction of polysaccharides from natural plants. Common extraction methods include water extraction, alcohol extraction and so on. In extraction, attention should be paid to controlling temperature, time and solvent concentration to improve extraction efficiency and product purity.

Separation: The polysaccharide substances in the extract are separated from other impurities. Commonly used separation methods include centrifugation, precipitation, extraction, etc. These methods allow polysaccharides to be separated from the extract and prepared for subsequent processing.

Modification: The separated polysaccharide is modified to introduce the required functional groups and structures to meet the chemical and physical properties of poloxam. Modification methods include oxidation, reduction, acetylation, etc. Natural products similar to Bloxham can be obtained by modification.

Refining and purification: After modification, polysaccharides need to be refined and purified to remove impurities and by-products. The common refining and purification methods include recrystallization, chromatographic separation, precipitation, etc. These methods can effectively improve the purity and yield of the product.

The advantage of natural extraction is that it uses natural raw materials and is friendly to the environment. However, this method has low production efficiency, unstable product quality and purity, and is limited by the origin and season of natural plants. Therefore, chemical synthesis is still the main production method in actual production.